CAT and infection: In fact, the transcription and the contrasting effects of the catalase gene deletions in C. glabrata and C. albicans matched their roles in animal infection models—C. glabrataCTA1 is dispensable in murine infections (82) (and human blood), while C. albicansCAT1 is required (83), as are other ROS-detoxifying genes such as SOD5. Why the lack of CTA1 in C. glabrata seems to very slightly increase survival is not immediately clear; however, a catalase-negative strain of Saccharomyces cerevisiae was shown previously to exhibit increased resistance to nitrosative stress (84).