In contrast to the study by Schulman et al, a recent prospective study by Coloma Bazán et al showed that there were no new thrombotic episodes in patients with low-risk APS who developed persistently negative aPL antibodies when taken off anticoagulation.56 This study was done in 11 patients with primary APS, but the follow-up period was only 20 months. This evidence concerns the gene FASLG and autoimmune polyendocrinopathy.