A systematic review showed that evidence linking the presence of aPL markers to subsequent thrombotic risk was low quality.52 Amory et al found that rates of death or re-thrombosis were not influenced by aPL results at baseline or follow-up.53 Our data show that recurrence of positive titres of aPL antibodies after initial negativity is common in APS due to SLE. Here, FASLG is linked to autoimmune polyendocrinopathy.