CAPN10 and diabetes mellitus: It was the first T2D susceptibility gene identified in linkage studies (Horikawa et al. 2000), with multiple subsequent GWAS or candidate gene studies having also identified an association between variants near CAPN10 and T2D risk and other diabetes-related phenotypes (Baier et al. 2000; Evans et al. 2001; Orozco et al. 2014; Ibrahim et al. 2015; Cui et al. 2016; Zhao et al. 2016; Bayramci et al. 2017; Hou et al. 2017; Castro-Martínez et al. 2018).