AFF2 and hereditary disease: Of these, 11 genes (AFF2, ATAD3A, CCDC22, CUL4B, HDAC8, MED12, RBMX, RFT1, UBE2A, USP9X, and VPS13B) have known links to neurodevelopmental disorders, two (ANO5 and CYBB) are involved in other genetic disorders, and associations between the remaining eight genes and genetic disorders are uncertain according to the OMIM database.