IL6 and insomnia: Chronic inflammation especially increased levels of C-reactive protein and IL-6 have been reported as the potential mechanism of the complications of insomnia [39, 175–177] same as increased incidence of infectious diseases, for instance, pneumonia [178], common cold [179], herpes zoster [180] and HIV [181], inflammatory diseases such as rheumatoid arthritis [182], heart failure [183], cardiovascular disease [184, 185], and cancer [186, 187].