IL6 and insomnia: It is shown that as a result of the systemic inflammation and inflammatory mediators overproduction such as TFN-α, IL-1β, IL-6, CRP, and COX-2, due to insomnia and sleep loss, we can detect changes in cellular components of the blood-brain barrier, particularly on brain endothelial cells and they can alter the blood-brain barrier permeability [332–337].