However, cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is one of the several cancer types (8 and 4 for TOP2A and CENPF, respectively) which showed most significant expression increase (ANOVA P < 1E-10 and fold change> 4) in tumor compared to normal tissues (Fig. 7a). The gene discussed is TOP2A; the disease is neoplasm.