In conclusion, our analysis suggested that TOP2A and CENPF are MRs that are overexpressed and activated in CC and synergistically regulate a common set of regulons, with functions related to cell cycle, DNA replication/repair, kinesin complex etc. Their high expression are linked to metastasis and the mutation status of a set of genes including a few tumor suppressors. The gene discussed is TOP2A; the disease is neoplasm.