Kaplan Meier curve with the log-rank test displayed that patients in high PCSK9 group had lower event-free survival rate compared with those in low PCSK9 group (p = 0.001, Fig. 2b) and DM subjects were more likely to occur future worse cardiovascular events compared to patients without DM (p < 0.001, Fig. 2a). Here, PCSK9 is linked to diabetes mellitus.