FasL as a pivotal apoptosis factor triggers the extrinsic cell apoptosis [25] and some research indicated that NFAT2 could bind to the FasL promoter effectively inducing the expression of FasL, which was applied to explain the phenomenon that NFAT2 overexpression induced HCC cells apoptosis [18]. This evidence concerns the gene NFATC1 and hepatocellular carcinoma.