As MT1-MMP dependent collagen degradation promotes remodelling of tissues during cancer progression [39], we determined the expression of collagen 12A1 (COL12A1, fibril associated collagen that modifies the interaction between collagen 1 and the surrounding matrix) in FT282, OVCAR4 and JHOS2 cells following TIMP-2 knockdown. This evidence concerns the gene MMP14 and cancer.