Durvalumab is high-affinity, human IgG1 monoclonal antibody that blocks PD-L1 from binding to programmed death 1 (PD-1) and CD80 [13]; a clinical trial proved the antitumor activity of durvalumab in patients with several advanced solid tumors such as NSCLC [14]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.