In addition, high levels of estrogen related to pregnancy can reduce the activity of lipoprotein lipase and lead to hypertriglyceridemia [13] There is an increased risk for AP when serum triglyceride levels are > 10 g/L (11.3 mmol/L) [14], which is why most cases of HTG-AP occurred during the third trimester of gestation. The gene discussed is LPL; the disease is alkaline phosphatase measurement.