CXCL12 and hemophilia: Among the synovitis biomarkers were also studied: plasma MMP-9, SDF-1a, soluble VCAM-1, serum calprotectin, (high sensitive) CRP, plasminogen, FDP, D-dimer, ferritin and MIF that were significantly increased in hemophilia patients compared to controls, whereas results for plasma leukocyte and serum lactic acid were unclear or contradictory.