Among the synovitis biomarkers were also studied: plasma MMP-9, SDF-1a, soluble VCAM-1, serum calprotectin, (high sensitive) CRP, plasminogen, FDP, D-dimer, ferritin and MIF that were significantly increased in hemophilia patients compared to controls, whereas results for plasma leukocyte and serum lactic acid were unclear or contradictory. This evidence concerns the gene PLG and hemophilia.