The levels of plasma epidermal growth factor (EGF), colony stimulating factor 2 (CSF2), interleukin 4/13 (IL4/13), fibroblast growth factor 2 (FGF2) and MIP-1 α were significantly lower in patients with a joint bleeding compared to patients without a bleeding or synovitis [35]. This evidence concerns the gene CSF2 and synovitis.