The aim of the present study was to investigate the association of the pre-treatment CRP level with recurrence-free survival (RFS), loco-regional control (LC), metastases-free survival (MFS), and overall survival (OS) in order to validate and further clarify the prognostic significance of the CRP level in a large European cohort of locally advanced rectal cancer patients treated with nRCT followed by definitive surgery. Here, CRP is linked to rectal cancer.