RRM2 and Parkinson disease: Relevant upregulations were detected for the cAMP-regulated DNA-damage sensor and mitosis initiator ARPP19 (cAMP regulated phosphoprotein 19), the splicing factor SRSF10 that was previously identified as PINK1-regulated [35], the circadian transcriptional coactivator CREBBP (CREB binding protein) that was implicated in PD [71], and the DNA-repair factor RRM1 (Ribonucleotide reductase regulatory subunit) that interacts with ferritin superfamily member RRM2 (Table 3).