In the context of human Parkinson pathogenesis, it is noteworthy that the main driver of neurodegeneration in PD, namely the excessive dosage and aggregation of the protein alpha-synuclein, can be modulated by iron via direct binding to an IRE in its mRNA 5′UTR as well as direct binding to the encoded protein [130,131]. The gene discussed is SNCA; the disease is Parkinson disease.