After iron overload with FAC (Supplementary Figure S2C), the Pink1−/− cells showed upregulations of MAP1LC3A probably as an effort to promote Parkin-independent mitophagy [67], and of SLC25A11 (Solute carrier family 25 member 11)/PANK4 (Pantothenate kinase 4)/PYGL/NUCKS (Nuclear casein kinase and cyclin dependent kinase substrate 1) as evidence for excessive mitochondrial metabolic performance, as well as innate immune responses such as SPP1 (Secreted phosphoprotein 1 possibly due to mitochondrial accumulation in this PD variant [68,69,70]. Here, SPP1 is linked to Parkinson disease.