On the other hand, iron shortage decreased the abundance of iron-binding nucleotide synthesis factors such as RRM2, of ISC biogenesis factors, and ISC-associated guardians of RNA/DNA stability, limiting also the transcriptional expression e.g., for Ppat, Nthl1, Dna2, Pold1, Tyw5, and Prim2, so the known vulnerability of the mitochondrial genome in PD might be enhanced in deleterious fashion by iron chelators. The gene discussed is POLD1; the disease is Parkinson disease.