PINK1 and Parkinson disease: To test whether the main effects observed in MEF can be reproduced also in human adult skin fibroblasts, we used cells from 7 healthy individuals versus 3 PARK6 patients with G309D-PINK1 mutation (experiment design in Figure 7A) that were previously shown to exhibit (i) lipid peroxidation, (ii) apoptotic vulnerability, (iii) expression dysregulation of the ferrireductase alpha-synuclein and the kinase LRRK2 (responsible for the PARK1/4 and PARK8 variants of PD, respectively), and (iv) abnormal mitoribosomal translation due to ABCE1 function impairment [14,17,116,117,118,119,120,121,122,123].