During transendothelial migration, both tumour and endothelial cells undergo dynamic morphological and cytoskeletal changes, and integrins β1 and β3, present on cancer cells and the endothelium, associated with a variety of α chains, are active participants in the cell–cell interactions or cell-specific matrix protein (e.g., laminin)–cell interactions [57,58,59,60,61]. Here, LAMB2 is linked to cancer.