Thus, it is tempting to suggest that PDIA1, the major isoform of PDIs in these cells, released from cancer cells as well as hLMVECs, contributes to regulating cancer cell adhesion to endothelium by supporting integrin-mediated adhesion, in a manner similar to that seen in interactions between leukocytes [6,7] or platelets [41] and endothelium. This evidence concerns the gene P4HB and cancer.