Since F11 receptor seems to be implicated in the maintenance of retinal pigment epithelium barrier, we then checked whether DME patients showing serous retinal detachment (SRD) at OCT examination showed also miR-199a-3p differential expression levels in AH respect to those not showing any SRD. The gene discussed is F11R; the disease is dopa-responsive dystonia due to sepiapterin reductase deficiency.