However, the results of our study have demonstrated that the HMGB1 polymorphisms rs1412125, rs1045411, and rs1360485 were associated with prostate cancer disease progression and severity (Table 3, Table 4 and Table 5), suggesting more consistency of HMGB1 SNPs in the oncogenicity of various cancers. The gene discussed is HMGB1; the disease is Familial prostate cancer.