For HMGB1 rs1412125, the HMGB1 rs1412125 polymorphic TC + CC genotypic variant was significantly associated with a higher D’Amico classification (OR = 1.405, 95% CI = 1.009–1.956; p = 0.044) compared with the TT genotype in 579 patients with prostate cancer (Table 3). This evidence concerns the gene HMGB1 and Familial prostate cancer.