TNFRSF8 and mycosis fungoides: BV is an antibody–drug conjugate composed of a humanized anti-CD30 monoclonal antibody and the antimicrotubule and cytotoxic agent monomethyl auristatin E. It has been associated with significant improvement in objective response lasting at least 4 months compared to the physician’s choice of methotrexate or bexarotene in CD30-positive MF or primary cutaneous anaplastic large-cell lymphoma in a multicenter, prospective, randomized phase III study [26].