Once in the systemic circulation, LPS act as a ligand for TLR-4, found in the membranes of cells that are part of the innate immunologic system and cells of the adipose tissue which favor the release of TNF-α and interleukins IL-1 and IL-6, among other pro-inflammatory cytokines, creating a low-grade inflammatory state capable of affecting insulin signaling and inducing insulin resistance. This evidence concerns the gene INS and Insulin resistance.