NOS2 and digestive system cancer: Other effects caused by SCFA inhibition of HDAC include the inhibition of neutrophil migration and the suppression of the transcription of genes involved in the response to LPS, decreasing the synthesis of pro-inflammatory mediators such as Nitric Oxide Synthase 2 (NOS2), IL-6, and IL-2 contributing to the maintenance of immune homeostasis and decrease of colonic inflammation [80].