SPP1 and obesity due to melanocortin 4 receptor deficiency: Additionally, a direct correlation between BMI and gene expression was observed for AGER, ANGPT2, CD68, IFI30, NOTCH3 and SPP1 (Figure 2A–F), whereas an inverse correlation was achieved for DLL4, PLIN, PNPLA2 and VEGF (genes that were down-regulated due to obesity) (Figure 2G–J).