When non-diabetic patients with obesity were analyzed, eleven genes were significantly modified; all of them overexpressed in SAT (ANGPT1, ANGPT2, CD68, DLL4, NOTCH3, PECAM1, PNPLA2, PTX3, SERPINF1, SPP1 and TNC) (Table 3 column 5). The gene discussed is NOTCH3; the disease is obesity due to melanocortin 4 receptor deficiency.