An RCT randomly assigned a trial diet with 28 g almonds or without almonds and the result indicated that the rise in GLP-1 concentration at 30 min post-meal was due to the effect of almond ingestion for both non-diabetic and T2DM groups [59].Based on the results of this study, we speculate that the role of a-LCD in improving depression in patients with T2DM may be associated with it stimulating the growth of SCFAs-producing bacteria, then increasing SCFAs and GPR43 activation, further maintaining GLP-1 secretion. The gene discussed is GLP1R; the disease is major depressive disorder.