CD8A and neoplasm: The resulting iCAF population was shown to have an impressively widespread impact on the immune landscape of the experimental tumors, promoting not only M2-polarization of tumor-associated macrophages (TAMs), but also an increase in intra-tumoral numbers of myeloid-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), regulatory B-cells (Bregs), and Th17 cells, as well as a decrease in CD8+ cytotoxic T-cells [189].