Through the presence of chemokines, cytokines, and other secreted factors (e.g., GM-CSF, CSF-1, IL-3, CXCL12, and CCL2), as well as other environmental clues, such as local anoxia and high levels of lactic acid, circulating monocytic cells are recruited to the tumor microenvironment and become tumor-associated macrophages (TAMs) [34,35]. Here, CXCL12 is linked to neoplasm.