ELANE and neoplasm: In contrast, N2 neutrophils have strong immunosuppressive and tumor-promoting activity, including the promotion of tumor angiogenesis, invasion, and metastases via various factors, such as hepatocyte growth factor (HGF) [122], oncostatin M [123], reactive oxygen species (ROS) [124], reactive nitrogen species (RNS), matrix metalloproteinase (MMPs), and neutrophil elastase (NE) [118].