A predominant Th2 (GATA3+) over Th1 (T-BET+) cell infiltration is detectable in pancreatic cancer and an increased ratio of GATA3+/T-BET+ tumor-infiltrating lymphocytes associated with disease progression, indicating a pathogenic shift towards a Th2 response [147,148,149]. The gene discussed is GATA3; the disease is familial pancreatic carcinoma.