The role of E-cadherin is extremely important in “shielding” micrometastases from chemotherapy as shown by Ma et al. in two studies in prostate cancer, where it was shown that hepatocytes induce a cMErT of prostate cancer cells via initial suppression of the MAP kinases p38 and ERK, conferring an epithelioid morphology to prostate cancer cells with an increase/re-expression of E-cadherin and other epithelial markers (ZO-1, connexin 43). The gene discussed is GJA1; the disease is Familial prostate cancer.