EGFR and breast carcinoma: By co-culturing breast cancer cell lines MCF-7 and MDA-MB-231 with hepatic non-parenchymal cells (NPCs) and endothelial cells, Taylor et al. showed that NPCs in the metastatic hepatic niche secrete factors inducing a mesenchymal shift in these epithelial breast cancer cells initiating outgrowth partly via EGFR signaling activation [72].