Compared with ex vivo experiments, NLRP3 and IL‐1β are up‐regulated and activated early after MI in a variety of cell types in the heart, not only infiltrating macrophages, but also fibroblasts, endothelial cells and border zone cardiomyocytes in the in vivo studies.8, 9. The gene discussed is IL1B; the disease is myocardial infarction.