One option follows reports showing that leukaemia‐associated translocation t(8;21) can be detected in hematopoietic cells of healthy individuals with no overt leukaemia [108, 109], and anthracycline‐related t(8;21) t‐AMLs were found to be positive for JAK2 V617F mutation [110], which suggests that t‐AML is the consequence of a series of genetic alterations. Here, JAK2 is linked to leukemia.