The signaling system such as Raf‐MEK‐ERK, the phosphoinositol 3 kinase (PI3K)‐protein kinase B (AKT)‐mammalian target of rapamycin (mTOR) and RalGDS‐RalA/B pathways or the TIAM1‐RAC1 pathway are open, stimulating tumor cells to grow, proliferate and spread, not affected by upstream signals from EGFR.13, 14, 15. The gene discussed is AKT1; the disease is neoplasm.