Furthermore, Peff at 0.256 (FOS) is an in-sensitive intracellular pressure, since transcription increases in case of both Bpa and Des exposures, while re-expression of stem cell required factor Klf4 at Peff 0.243, and Wnt5A or Esr2 that are expressed at Peff 0.136 could be considered markers for an increased early developmental risk of neotransformation, or temporally for delayed clear cell carcinoma risk in aged cells with acquired mutations over time. The gene discussed is DES; the disease is clear cell adenocarcinoma.