RRM1 and amyotrophic lateral sclerosis: We then tested the anti–RRM1 TDP43 E6 antibody on tissues from 10-month-old mice overexpressing human mutant TDP43A315T, a mouse model that shows histopathological and phenotypical features of ALS/FTLD pathology such as TDP43 proteinopathy (24) (Figure 1D and Supplemental Figure 1C).