Because of TDP43 proteinopathy, ALS and FTLD are now recognized as a disease continuum (7), but the same TDP43 alterations can also be observed in other disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and vascular dementia (1, 8, 9). This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.