Similar study conducted in T2D patients suggested that within SAT, mRNA and protein levels of adipokines, such as leptin, serum amyloid A (SAA), and transmembrane 4 L six family member 1 (TM4SF1), were elevated in very large subcutaneous adipocytes compared with small adipocytes [60]. Here, TM4SF1 is linked to type 2 diabetes mellitus.