HAVCR2 and Sepsis: Rather than depleting NKT cells, some studies have tried to skew the NKT cells response to achieve favorable outcomes in sepsis: administration of altered lipid antigens (e.g., OCH), cytokines (e.g., IL-30), and immune checkpoint modulators (e.g., Tim-3 ligands) shift iNKT cells toward the more regulatory subtypes and have demonstrated improved outcomes in experimental sepsis (119-121).