To identify the mediator of TSP‐2‐promoted osteosarcoma migration, we examined levels of MMP‐1, MMP‐2, MMP‐3, MMP‐7, MMP‐9, MMP‐12 and MMP‐13 mRNA expression following TSP‐2 stimulation (Figure 2A,B). This evidence concerns the gene THBS2 and osteosarcoma.