In 2017, Chen et al used miR‐376c mimic stimulation to suppress TSP‐2‐induced MMP‐2 expression and cell motility, and demonstrated that administering TSP‐2 knockdown to prostate cancer cells abolished osteolytic metastasis in vivo,23 revealing that TSP‐2 has dual functionality in cancer progression. This evidence concerns the gene MMP2 and Familial prostate cancer.