Two recent studies demonstrated that, in pancreatic cancer, combinations of pharmacologic inhibitors that concurrently block both ERK and autophagy may be effective treatments for pancreatic cancer,24, 25 so it is worth to study in the future whether concurrent blockade of both ERK and autophagy will have promising effects on LUAD with DEPDC1 high expression. Here, DEPDC1 is linked to familial pancreatic carcinoma.