Although autophagy plays a dual role in tumorigenesis,18 based on a previous report that autophagy inhibition was associated with increased clonogenic survival in NSCLC cells both in vitro and in vivo,23 it is more likely that DEPDC1 inhibition of autophagy should have positive contribution to LUAD tumorigenesis. Here, DEPDC1 is linked to non-small cell lung carcinoma.