The most frequently reported AEs in the expansion part (≥10%) were fatigue (n = 14, 35%), diarrhoea (n = 18, 45%), ocular symptoms (n = 14, 35%), pain (n = 14, 35%), decreased appetite (n = 13, 33%), nausea (n = 12, 30%), dyspnoea (n = 9, 23%), vomiting (n = 8, 20%), anaemia (n = 14, 35%), alanine aminotransferase (ALT) increase (n = 10, 25%) and aspartate aminotransferase (AST) increase (n = 9, 23%). This evidence concerns the gene GPT and anemia (phenotype).