BRCA1 and breast cancer: In particular, germline BRCA1 pathogenic variant carriers (g-BRCA 1 PV) have a lifetime risk of 65–80% of developing BC and 37–62% of developing OC, while BRCA 2 pathogenic variant carriers (g-BRCA 2 PV) have a lifetime risk of 45–85% for BC and 11–23% for OC respectively1–5.