Furthermore, Galectin-3 clearly enhanced migrative and invasive ability of NPC cells as the overexpression of Galectin-3 in 6-10B cells exalted its ability to migrate and invade, whereas the gal-3 silencing in 5-8F cells and its inhibition in both 5-8F and Galectin-3 overexpressing 6-10B cells greatly reduced cell migration and invasion (Fig. 5D–G). Here, LGALS3 is linked to nasopharyngeal carcinoma.