Compared with the patients with AST/ALT < 1.38 on admission (n = 367, 64.7%), patients with AST/ALT ≥ 1.38 were older (median age, 60 years [IQR, 37.3–71] vs 51 years [IQR, 37–64]; P = 0.001), more likely to have myalgia (64 [32%] vs 79 [21.5%]; P = 0.006), fatigue (91 [45.5%] vs 117 [31.9%]; P = 0.001) and some coexisting diseases, such as COPD (19 [9.5%] vs 17 [3%]; P = 0.023), cardiovascular diseases (28 [14%] vs 25 [6.8%]; P = 0.005) and chronic kidney diseases (19 [9.5%] vs 12 [3.3%]; P = 0.002), on admission. This evidence concerns the gene GPT and chronic obstructive pulmonary disease.