NF-κB represents one of the most important signaling pathways due to its transcription induction of many key-genes in cancer development, such as genes for proliferation (e.g. Cyclin D1 [CCND1], Cyclin E), apoptosis (e.g. Blc-2, Bcl-xL), angiogenesis (e.g. VEGF, IL-8, HIF1α), cell adhesion and metastasis (e.g. ICAM, MMP, iNOS), survival (e.g. Survivin) and inflammation (e.g. TNF-α, COX2, iNOS)3. The gene discussed is NFKB1; the disease is cancer.