Consequently, these complexes regulate the transcription of genes in the nuclei thereby mediating several cellular functions such as proliferation (e.g. Cyclin D1, Cyclin E, IL-6), tumor promotion (e.g. VCAM, ICAM, iNOS, COX 2), apoptosis (e.g. Bcl-2, Bcl-xL, Survivin) and inflammation (e.g. TNF-α, COX2, iNOS)3,22. The gene discussed is CCND1; the disease is neoplasm.