For example, the c-Myc-responsive lncRNA isocitrate dehydrogenase (IDH) 1 antisense RNA1 (IDH1-AS1) supresses cancer cell proliferation through a metabolic mechanism26, whereas p53 regulates the expression of the lncRNA GUARDIN that is essential for genomic stability and thus promotes cancer cell survival27. The gene discussed is TP53; the disease is cancer.