For example, the c-Myc-responsive lncRNA isocitrate dehydrogenase (IDH) 1 antisense RNA1 (IDH1-AS1) supresses cancer cell proliferation through a metabolic mechanism26, whereas p53 regulates the expression of the lncRNA GUARDIN that is essential for genomic stability and thus promotes cancer cell survival27. This evidence concerns the gene LNCTAM34A and cancer.