In accordance, c-Myc co-precipitated the MILIP promoter and siRNA silencing of c-Myc reduced the expression of MILIP along with the lncRNA OVAAL known to be regulated by c-Myc in human A549 lung adenocarcinoma, MCF-7 breast cancer, and HCT116 colon cancer cells (Fig. 1a, b, Supplementary Fig. 2b, c)33. This evidence concerns the gene MYC and breast cancer.