Moreover, while some correlative data exists for distinct mutational landscapes influencing differences in cellular environment, analysis of the TCGA database validating elevated levels of IL-33 in the GBM patient cohort (Supplementary Fig. 2e) did not find a correlation with any obvious genetic descriptor, including molecular subtype, MGMT methylation status, or common mutations (e.g., p53, PTEN EGFRVIII). The gene discussed is PTEN; the disease is glioblastoma.