Tyrosine-specific phosphoproteomic analysis of IL-33+ tumors showed an increase in a number of phospho-peptides derived from STAT3, CDK1, CDK2, FYN, MAPK14, and MAPK3 (Fig. 8a), some that based on amino acid sequence could be attributed to either human glioma or mouse host origin. Here, MAPK3 is linked to central nervous system cancer.