AIF1 and central nervous system cancer: As shown in Fig. 3c and Supplementary Fig. 3c, ectopic expression of the full-length IL-33 in both glioma lines resulted in a dramatic increase in tumor growth with a concomitant increase in Iba1+ TAMs and a significant decrease in the overall survival (p < 0.0001; Fig. 3d and Supplementary Fig. 3d).