CD81 and central nervous system cancer: As predicted, we observed a transition from IL-33 enriched inflammatory monocytes100 (marked by expression of Ccr2, Ifitm2, and Ifitm3) to differentiating BMDM and then to glioma-associated BMDM107,110,111 (marked by expression of Apoe, Hexb, and Cd81) consistent with a pro-tumorigenic environment.