Mining both the TCGA database and our own patient glioma RNA-seq database65,124 provided additional evidence for the expression of IL-33 in ~50% of high-grade glioma, with little or no expression in low-grade glioma, astrocytoma, or other brain tumors (www.cBioportal.org). Here, IL33 is linked to astrocytoma (excluding glioblastoma).