The presence of IL-33 was not limited to human glioma as IL-33 was observed in specific murine models of GBM, including a syngeneic Nfl−/+/Trp53−/+ model79,125,126 and PDGFB-driven tumors that have a more mesenchymal stroma-like phenotype80. The gene discussed is PDGFB; the disease is central nervous system cancer.