From the data demonstrating similarities in GIPR ligand-mediated desensitization in primary mouse adipocytes, primary human adipocytes, and mouse Neuro-2a neuroblastoma cell lines, we hypothesize that pharmacological GIPR agonism does not only desensitize GIPR in adipocytes, but may perhaps be a feature of cell types with relatively low levels of GIPR expression. Here, GIPR is linked to neuroblastoma.