GIPR and neuroblastoma: As previously reported in the literature10,25, this data demonstrates ligand-mediated GIPR desensitization due to ligand-induced internalization that, at least in mouse primary adipocytes and Neuro-2a neuroblastoma cells, occurs within 24 h (Fig. 7d, g) and does not regain sensitivity for over 48 h (Fig. 7b), which explains why chronic GIPR agonism functionally mimics GIPR antagonism.