ECTV, in turn, downregulated the expression of Birc3 and Tnfrsf12a. In poly(I:C)-treated cells, ECTV infection resulted in the inhibition of Birc3, Cd40, Chuk, Nfkb2, and Tnfrsf11a. In IFN-γ + LPS-treated cells, in turn, ECTV inhibited the expression of Birc2, Birc3, Cd40, Chuk, Ifngr1, Ltbr, Nfkb2, Tlr4, Tnfrsf11a, and Traf2 (Figure 9B). The gene discussed is CHUK; the disease is infection.