To test the relevance of this residue on the stability of Chk1 in NSCLC cells, we transfected H460 cells with either Myc-Chk1 or Myc-K436R mutant Chk1, and treated these cells with CHX for 0, 3, 6, and 24 h. This evidence concerns the gene MYC and non-small cell lung carcinoma.