For instance, tamoxifen treatment of MCF-7 breast cancer cells prevented estradiol-stimulated HDAC6 accumulation and α-tubulin deacetylation [57], and nitric oxide (NO) is able to increase the acetylation of α-tubulin in A549 cells by preventing the essential S-nitrosylation of HDAC6 [58]. This evidence concerns the gene HDAC6 and breast carcinoma.