GAPDH and myeloid sarcoma: It has been shown that microglial EVs and particularly MVs are enriched in pro-inflammatory mediators, such as IL-1β [67] and TNF-α [76], and the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) [77], thus propagating inflammatory stimulus throughout the brain and enforcing inflammation in neuroinflammatory diseases such as MS [78] (Figure 2a).