We have previously demonstrated that uL3 is a key mediator of nucleolar stress induced by several chemotherapeutic drugs, including 5-fluorouracil (5-FU) [34,35,36], Oxaliplatinum (OHP) [37,38], Actinomycin D (Act D) [39,40] and Niclosamide, in p53-mutated lung and p53-deleted colon cancer cells [41,42]. Here, TP53 is linked to malignant colon neoplasm.