Among these, HIF-1α (hypoxia-inducible factor-1 alpha) induces the expression of BNIP3/BNIP3L (atypical BH3-only proteins the Bcl-2/E1B 19 kDa-interacting protein 3) that, in turn, favors the dissociation of Bcl-2-Beclin1 complexes, activates autophagy and promotes tumor progression [16]. This evidence concerns the gene BECN1 and neoplasm.