Since the ability of dl922-947 to induce DNA lesion accumulation associates with its efficacy [27] and given that DDR inhibitors can favor this mechanism of action [26,27,28], in the present study, we analyzed whether the abrogation of the G2/M DNA damage checkpoint through the WEE1 inhibitor AZD1775 enhanced MM cell sensitivity to dl922-947. Here, WEE1 is linked to Miyoshi myopathy.