GRK2 and obesity due to melanocortin 4 receptor deficiency: In addition, using a mouse model of myeloid-specific GRK2 targeting, we show that decreasing GRK2 levels in myeloid cells limits diet-mediated upregulation of pro-inflammatory cytokines and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in PVAT, leading to reduced obesity-induced loss of vasodilation and preserving vascular function.