Moreover, an increased production of ROS leading to a loss of the anti-contractile effect of thoracic PVAT was demonstrated in a different murine model [32], and enhanced NADPH oxidase and superoxide anion production has been found in thoracic PVAT of mice after an 8-week-long HFD (60% Kcal from fat), which results in endothelial dysfunction [33]. The gene discussed is FMO5; the disease is endothelial dysfunction.