Previously, we demonstrated that Lsp1 deficiency directly increases CD4+ T cell migration in response to stromal cell-derived factor-1, a major chemokine that is known to be involved in CD4+ T cell migration under arthritis-associated conditions.13 In this study, we tested whether LSP1 affects CD8+ T cell migration under tumor-associated conditions. This evidence concerns the gene LSP1 and arthritic joint disease.