Among TILs, the myeloid cell population is another substantial component of the TME that regulates tumor growth.1 8 Interestingly, the frequency of CD11b+Ly6ClowF4/80high tumor-associated macrophages (TAMs) was also significantly decreased in the tumors of Lsp1 KO mice compared with those of WT mice, although the frequency of CD11b+ myeloid cells was similar between Lsp1 KO and WT mice (online supplemental figure 2D and figure 1G). The gene discussed is ITGAM; the disease is neoplasm.