We demonstrated that Lsp1 deficiency in T cells suppresses the growth of B16 melanoma in mice, which seems to be mediated by increased infiltration of CD8+ T cells into tumor sites and by enhanced production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), antitumor effector cytokines, by T cells. Here, CD8A is linked to melanoma.