In vitro functional tests demonstrated that Lsp1-deficient CD8+ T cells had increased chemotactic activity via the p-Akt signaling pathway on CXCL9 and CXCL10 stimulation, the major chemokines involved in T cell trafficking towards tumor sites, whereas Lsp1-overexpressing CD8+ T cells showed the opposite response. This evidence concerns the gene AKT1 and neoplasm.