As a result, in WT mice, the distribution of immune cells, particularly T cells, showed a representative ‘infiltrated-excluded’ type of tumor, in which Ly6Clow F4/80high TAMs prevent CD8+ T cell infiltration into the tumor core.26 By contrast, in Lsp1 KO mice, CD4+ and CD8+ T cells were frequently found in the tumor core and their distribution represents an ‘infiltrated-inflamed’ tumor phenotype, in which cytotoxic T cells are heavily infiltrated and have potent antitumor activity.26 This evidence concerns the gene CD8A and neoplasm.