We anticipate that Lsp1 depletion in T cells may convert immune-deficient ‘cold’ tumors to immune-sufficient ‘hot’ tumors, as depicted in figure 6E, which may serve as an effective strategy to overcome the current limitations of T cell-based immunotherapy and to improve the efficacy of immune checkpoint blockades and tumor vaccination44 for solid tumors. Here, LSP1 is linked to neoplasm.