This study also demonstrates that genetic ablation of Lsp1 in T cells improves antitumor immune response to B16 melanoma, probably by promoting T cell migration into tumor sites and by upregulating IFN-γ and TNF-α expression in T cells, which ultimately leads to the conversion of TMEs from ‘immune-resistant’ to ‘immune-susceptible’. The gene discussed is LSP1; the disease is melanoma.