As shown in figure 6B, Lsp1-deficient T cells more strongly repressed tumor progression in Rag1 KO mice challenged with B16 melanoma as compared with Lsp1-overexpressing T cells and vehicle alone (without mature T cells), which confirms that loss of Lsp1 in T cells specifically mediates the antitumor effect. The gene discussed is LSP1; the disease is neoplasm.