LSP1 and cancer: For example, genetic variation in LSP1 has been implicated in susceptibility, prognostic outcomes and as a diagnostic marker in diverse types of cancers.14–19 21 Moreover, a recent study showed that high LSP1 levels in glioblastoma serve as an independent predictive factor of unfavorable prognosis.22 However, it remains unclear whether LSP1 in T cells directly regulates tumor growth and how it contributes to the pathogenesis of cancers.