As shown in online supplemental figure 5, no differences were found in the frequencies of CFSE-diluted cells or annexin V+ and/or PI+ cells in CD4+ and CD8+ T cells between the two groups of mice, suggesting that other mechanism(s) than cell proliferation and survival are responsible for the decrease of TILs in the melanoma of Lsp1 Tg mice. The gene discussed is ANXA5; the disease is melanoma.