In the tumor, however, they were significantly higher in the infiltrated CD4+ and CD8+ T cells of Lsp1 KO mice than in those of WT mice (figure 5A, B), suggesting that Lsp1 deficiency increases antitumor immunity by inducing TNF-α+ and IFN-γ+ expression in tumor-infiltrating T cells. This evidence concerns the gene CD8A and neoplasm.