Studies aiming to determine the role of bioactive lipids in the pathophysiology of T2D are in their infancy, and a particular focus is the interaction between lipids and inflammation.22 Indeed, 12S-HETE signalling is implicated in the control of multiple physiological functions, and it could be associated with deleterious23 or beneficial18 effects, including neuroprotection, as in the case of MOR24 and PPARγ signalling.25 In our experimental model, only the level of 12-HETE was significantly increased in the colon of mice fed a HFD45% supplemented with FOS. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.