This activation of endothelial autophagy from the extracellular matrix is considered “noncanonical” as it happens in nutrient-rich conditions and results in secretion of anti-angiogenic thrombospondin-1 (101, 102), profound catabolism of endothelial vascular endothelial growth factor A (VEGFA) (103, 104), and marked suppression of tumor angiogenesis (105). Here, VEGFA is linked to neoplasm.