IGFBP2 and pulmonary arterial hypertension: In the current study, we measured IGFBP2 and total IGF1/2 levels in two independent PAH cohorts, as well as a healthy control cohort to evaluate the value of these proteins as diagnostic biomarkers for PAH; we then evaluated the relationships of these protein biomarkers with PAH progression and severity; finally, we evaluated IGFBP2 in the human PAH lung and pulmonary vascular cells.